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Abstract #1089

T1rho MR Is Sensitive to Changes in Normal Appearing White Matter and Gray Matter in Multiple Sclerosis

Jay Gonyea1, Christopher G. Filippi2, 3, Angela Applebee2, Trevor Andrews1, 4, Lindsay Karr, Scott Hipko1, Richard Watts1

1Department of Radiology, University of Vermont College of Medicine, Burlington, VT, United States; 2Department of Neurology, University of Vermont College of Medicine, Burlington, VT, United States; 3Department of Radiology, Columbia University Medical Center, New York, NY, United States; 4Philips Healthcare, Cleveland, OH, United States

Quantitative T1&[rho] maps were calculated for 13 MS patients and 17 age-matched control subjects using a novel 3D fluid attenuated variable flip angle turbo-spin echo acquisition. The resulting high SNR whole-brain T1&[rho] maps were then segmented into white and gray matter, and spatially normalized. Significant differences between MS patients and controls were found in cortical gray matter (p=0.007), juxtacortical white matter (p=0.003) and major white matter tracts (p=0.002). The sensitivity of quantitative T1&[rho] imaging to the macromolecular content of tissue may provide an important biomarker of changes in normal-appearing white- and gray-matter in MS and other neurodegenerative diseases.

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Keywords

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