Meeting Banner
Abstract #1073

Evaluation of Cerebellum and Globus Palidus by in vivo Diffusion Tensor Imaging in a Rat Model of Bilirubin Encephalopathy

Dominik Maria Reisinger1, 2, Jiangyang Zhang3, Joel Marx1, Michael Porambo1, Michael V. Johnston1, Seyed Ali Fatemi1, 2

1Neuroscience, Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, United States; 2Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Despite the preventable nature of bilirubin encephalopathy, classically known as Kernicterus, cases continue to occur and remain a significant problem in newborns. A mutant rat model, referred to as the Gunn rat, features an enzyme deficiency resembling Crigler-Najjar syndrome of the human. Sulfadimethoxine will be used to exaggerate bilirubin encephalopathy. This way we tried to resemble Kernicterus in the newborn and further evaluated the model through acquiring high-resolution images of T2-weighted sequences as well as in vivo diffusion tensor imaging (DTI) of the Gunn rat.

Abstract PDF

Keywords

abnormal accumulation acute acutely addition animals anisotropy array ataxia atrophy audience baron carried cerebellar cerebellum cerebral channel child chronic coil color consecutive controls correlate cross decrease decreases determine devastating developed diameter differ diffusion disability disorder displaces either encephalopathy encoded enhance evaluation exhibit exhibited finding findings fractional front genetic gradient highly horizontal hours illustrating implicates in vivo indicated induced inferior institute interestingly involving jaundiced johns leads manual maps maria measured medicine middle model models mutant mutations neurological neurologists neurology neuropathology newborn newborns objective outlined palsy pathologically patients peduncle pilot postmortem postnatal preferentially profound quadrature radiologist radiology rats receive recessive reported resolution saline scanner school scientists secondary section segmentation serve served severe severity slices solemnly spin staining studies syndrome target tensor therapeutic towards toxicity tracts transmit treated trend type understanding volume volumes whereas whether white wild yellow