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Abstract #1033

Iron Deposition Influences Measurement of Water Diffusion Tensor in the Human Brain: A Combined Analysis of Diffusion and Iron-Induced Phase Changes.

Xiaojun Xu1, Qidong Wang2, Minming Zhang1

1No.2 Hospital Zhejiang University School of Medicine, Hangzhou , Zhejiang, China; 2No.1 Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

We found that increased iron deposition would cause a decrease in the estimated diffusivity and an increase in the estimated anisotropy. This finding indicates that iron deposition influences significantly the measurement of water diffusion tensor in the human brain. Caution is needed in use of DTI metrics for diagnosis of various neurological diseases involving abnormal iron or other paramagnetic substances deposition, particularly at higher fields.

Keywords

abnormal access accumulation acquisition adults advanced advancing affect aging analyzed anisotropy authors basis brain built cause caution china chose collected combined commonly concentration considered consistent contrast corrected correlation counteract create decrease decreased decreases deep dependence deposition deposits diagnosis diffusion diffusivity diseases distortions eddy elevated especially established estimation evaluate examine excluding explanatory filter filtered filtering finding frontal furthermore greater healthy hospital human impact independent indicated indicates induced influence influenced influences intensity involving iron life linear linearly lobe local mainly many marginal matrix meanwhile measured medicine metrics models motions needed negative neurological occurred original outcome pass previous recorded reduced reflection regional regression related relationship remove reported reports retrospectively reviewed sample scaling scanner school shot significance significantly skewing slice span statistical statistically studies suggested suggests susceptibility tended tensor tissue translating typically underlying usually variables various water whereas white years