Meeting Banner
Abstract #1010

Altered Causal Connectivity of Resting State Brain Networks in Amnesic MCI

Peipeng Liang1, Zhihao Li2, Gopikrishna Deshpande3, Zhiqun Wang1, Xiaoping P. Hu2, Kuncheng Li1

1Dept. of Radiology, Xuan wu Hospital, Capital Medical University, Beijing, China; 2Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States; 3Department of Electrical and Computer Engineering, and Department of Psychology, Auburn University, Auburn, AL, United States

The present study applied correlation-purged Granger causality analysis (CPGC) to investigate the effective connectivity of four basic networks in 16 aMCI patients and 16 matched healthy controls C default mode network (DMN), hippocampal cortical memory network (HCMN), dorsal attention network (DAN) and fronto-parietal control network (FPCN). It was found that, as contrast to healthy controls, aMCI exhibited significantly reduced within-FPCN (anterior-posterior) and hippocampus centered causal connectivity, together with enhanced within-DMN and within right frontal cortex causal connectivity. The current study demonstrated the coexistence of causal disconnection and compensation in aMCI patients, and might provide insights into biological mechanism of the disease.

Abstract PDF Poster PDF

Keywords

alterations altered although amnesic among anterior applied atrophy attention auburn basic biological biomedical brain called capital causal causality china coexistence coexisting cognitive collected compensation computer concentrated connectivity control controlling controls correlated correlation cortex cortical covariates decline decreased default dept disconnection disconnections disease domain dorsal effective electrical engineering enhanced examination examine extends findings firstly frontal functional gender global granger healthy hospital impairment insights institute investigate kept learning links matched measured mechanism medical memory mental might mild mini mode network networks parietal pathways patients patterns posterior power previous psychology purged radiology reduced remained resting severity significantly statistical still structural studies substrates suggest taking technology underlying verbal