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Abstract #1009

Long-Term Environmental Enrichment Induces CA1 Enlargement in APPswe/PS1dE9 Transgenic Mice: A Deformation-Based Morphormetry Study

Dai Shan1, Shuxia Wang1, Yong Fan2, Fuchun Lin1, Hao Lei1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China; 2National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China

The effect of enriched housing of Alzheimer's disease (AD) transgenic mice is still in dispute. In this study, we aimed to investigate whether enriched environment treatment will cause macrostructural changes in the brain of APPswe/PS1dE9 transgenic mice. Deformation-based morphormetry (DBM) was used to analyze the anatomical magnetic resonance imaging data.

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