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Abstract #0989

Chemotherapy-Induced Structural Changes in Cerebral White Matter in Breast Cancer Patients: A Longitudinal DTI Study

Jeremy Moreau1, Arturo Cardenas-Blanco2, Santanu Chakraborty2, Mark E. Schweitzer2, Carole Scherling3, Joyce Mackenzie, Barbara Collins4, Andra Smith1

1School of Psychology, University of Ottawa, Ottawa, Ontario, Canada; 2Diagnostic Imaging, The Ottawa Hospital, Ottawa, Ontario, Canada; 3Memory and aging center, University of California, San Francisco, San Francisco, CA, United States; 4Neuropsychology, The Ottawa Hospital, Ottawa, Ontario, Canada

Chemotherapy used in the treatment of breast cancer has been associated with damage to myelin. Hence investigating white matter changes in breast cancer patients following chemotherapy could aid in the understanding of chemotherapy related cognitive impairment. this study we assesses FA in a group of breast cancer patients prior to and at two time points following chemotherapy treatment. The results suggests: i) Quantitative DTI biomarkers are sensitive to detect structural changes induced by chemotherapy ii) chemotherapy impacts white matter in important areas of the brain. iii) Alterations, detected as changes in FA, recover 1 year post-chemotherapy to near pre-chemotherapy levels.

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Keywords

activation administered affine aligned alters among analyses anisotropy arbitrarily assessed assessment attention attrition battery biology body bottom brain breast cancer carried cerebellar cerebral chemotherapy clinical cluster cognitive coincide collinear common completion complications controlled controls corpus correct create decreases deficits define derived detect detected diagnostic diffusion direct distortions dominant education eigenvalues empirical experimental female flirt flow focus fractional frontal frontiers functional functioning generated gradient handed hence hospital human identified impairment individual individually induced inhibition initial inspected integrity intervals journal knowledge like linear longitudinal mapping maps masks matched measure mechanisms memory motion none nonlinear oncology package paired parametric patient patients patterns permutation permutations poorly post previous prior processing produce prominent quantitative random recovers recruited reductions registration related report scanner school significantly skeleton smith software space spatial speed spin statistical statistics structural studies subject subjects suffering suggestive suppl survival technical template tensor threshold tract treatment underlie underlying understanding vertical weeks white whole widespread year