Meeting Banner
Abstract #0988

Amide Proton Transfer Imaging for High-Grade and Low-Grade Brain Tumors

Masahiro Ida1, Toshiki Wakayama, Katsutoshi Murata2

1Department of Radiology, Tokyo Metropolitan Ebara Hospital, Oota-ku, Tokyo, Japan; 2Research and Collaboration, Siemens Japan, Shinagawa-ku, Tokyo, Japan

We evaluate whether amide proton transfer (APT) imaging can provide additional information in differentiating malignant brain tumors (WHO grade III & IV) from benign tumors (grade II) and chemotherapy-induced pseudoprogression and irradiation necrosis. APT imaging was performed at 3-tesla using a gradient-echo sequence for CEST (W.I.P) with thirteen frequency offsets (4.5ppm). Increased APT signal was observed in tumor tissues in grade III and IV. However, no elevation of APT signal was recognized in grade II tumors, chemoradiation-indueced pseudoprogression and necrosis. APT imaging can provide adjunct information utilized for differentiating malignant brain tumors from benign tumors and post-therapeutic necrosis.

Abstract PDF Poster PDF

Keywords

added adjunct agent amide asymmetry benign brain bulk called channel chemical chemotherapy clinical coil collaboration combination concentration confirmed consisted contrast core cystic degree dependent detects diagnose diagnosed differentiating diffuse diffusion discuss displays dynamic elevation endogenous enhancing enrolled evaluate evaluating examinations exchange exogenous flair frequency gadolinium grade gradient head health hospital identified indirectly induced irradiation japan lobes malignant materials metropolitan mobile necrosis need neoplasms occipital offset offsets organization patients peptides perfusion portion portions possibility post power progress proteins protocol proton protons radiology recognized role saturation solid studied system therapeutic thirteen tissues transfer trio tumor tumors type useful utilized varying viability visible water whether world