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Abstract #0895

Serial Structural Imaging in the Postpartum Period Reveals Increases and Decreases in Regional Brain Volumes Following Childbirth

Derek K. Jones1, Tim Vivian-Griffiths1, C John Evans1, Nicholas Lange2

1CUBRIC, School of Psychology, Cardiff University, Cardiff, Caerdydd, United Kingdom; 2Neurostatistics Laboratory,Harvard School of Public Health, Harvard Medical School, Boston, MA, United States

This study performed serial structural MRI on a cohort of mothers in the early postpartum period. Compared to matched controls, there were both increases and decreases in brain volume in the new mothers over time - but not in the matched controls.

Keywords

acquisition affect analyses anterior applied assumed audience authors behavior bilaterally biological biometrics birth brain brains caudal child cognitive complications computing context control controls correlation cortex cortical covariates criterion date decreased decreases decreasing delivery derived detail detect distinct drops equal excluded expectant exploratory extent extreme final fisher foundation frontal functions grateful gray greater health healthy hemisphere home hypothesis identification identified included inclusion increasing initial initially interpretations john lacks laird last leaving limiting linear literature longitudinal matched maternal measure measured measures mixed models months mother mothers nine noted overcome participant participants percent period pilot pole postpartum potentially precision predictors pregnancy public puerperal recalled recovery recruited regional repeated replicate residual revealed roughly sample scanning school sciences section segmentations serial several shrinks simple simplest simultaneous since slow software soon spatial springer stat statistics structural subject subjects system table tailed target technical terms track trends unexpected variability variables variances varied volume volumes waterloo whole whose wise