Massimo Filippi1,
Paola Valsasina1, Paolo Misci1, Andrea Falini2,
Giancarlo Comi3, Maria A. Rocca1
1Neuroimaging
Research Unit, Institute of Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan, MI, Italy; 2Department
of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San
Raffaele University, Milan, MI, Italy; 3Department of Neurology,
San Raffaele Scientific Institute, Vita-Salute San Raffaele University,
Milan, MI, Italy
In this study, we explored gender- and age-related effects on resting state (RS) functional connectivity within and among networks with potential functional relevance. RS data were acquired from 285 healthy controls (148 men and 137 women, range=8-79 years). Abnormalities of connectivity within and among networks, as detected by independent component analysis and functional network connectivity, were found in almost all RS networks; however, age and gender effects were variable across networks. Our results might contribute to the understanding of gender-related differences in the pathobiology of aging.