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Abstract #0738

Impact of Cocaine Use on Brain Metabolism: Hypoactivity, Dose Dependence, and Relationship to Cognitive Ability

Peiying Liu1, Bryon Adinoff2, 3, Carol Tamminga2, Francesca Filbey4, Hanzhang Lu1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3VA North Texas Health Care System, Dallas, TX, United States; 4Center For Brain Health, University of Texas at Dallas, Dallas, TX, United States

Long-term cocaine use is known to negatively impact neural systems. Cerebral metabolic rate of oxygen (CMRO2) is thought to be a direct index of neural activity, but no measurements of brain oxygen metabolism in cocaine-addicted patients has been reported. We used a non-invasive, fast and reliable MR method to examine impact of long-term cocaine use on CMRO2. We sought to answer three questions: 1) is CMRO2 in cocaine-addicted participants significantly different from that in healthy controls? 2) is there a relationship between cocaine use and the severity of metabolic deficit? 3) does the degree of CMRO2 deficit predict cognitive ability?

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Keywords

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