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Abstract #0737

Hippocampal Choline Level Predicts Symptomatic Improvement with Agomelatine in Major Depressive Disorder: A 3 Tesla Single Voxel Spectroscopy Study

Najib Allali1, 2, Romain Valabregue2, Malgorzata MarjanskaA3, 4, Pauline Delaveau1, ric Bardinet2, Maritza Jabourian5, Judith LAREDO5, Philippe Fossati1, 6, Stphane Lehricy2, 7

1USR 3246, CNRS, Paris, le-de-France, France; 2Centre de Neuroimagerie de Recherche - CENIR, Institut du Cerveau et de la Moelle pinire - ICM, Paris, le-de-France, France; 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 4Department of Radiology, University of Minnesota, Minneapolis, MN, United States; 5Institut de Recherches Internationales Servier - IRIS, Courbevoie, le-de-France, France; 6Psychiatry, APHP - GH Piti Salptrire, Paris, le-de-France, France; 7UMR-S975 ; Inserm, U975 ; CNRS, UMR 7225, Paris, France, CRICM, Universit Pierre et Marie Curie, Paris, le-de-France, France

In this study, we sought to identify spectroscopic correlates of depressive state and of response to Agomelatine, a new antidepressant with melatonin agonist and 5-HT2C antagonist properties.

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Keywords

acquisition action analyses analyzed antidepressant antidepressants arch array assessed axis basis biological block body brain cell channel choline chronic clinical coil compliance compounds concentration concentrations consisted control correlates correlation cover curie daily date decrease decreased depression depressive detected diagnostic dimensional discovery disorder disorders drug edition evaluating every evidence examination examinations excellent excitation existing field fits five glutamate good gray growing head healthy highly humans identify implication improvement in vivo included indicate indicating induced infrequently investigated involvement laser location long major manual marker matched mechanism medication membranes mental metabolite metabolites natl nature need needed neurobiology oral partial patient patients placed plot poor positive predicts protocol proton psychiatry quantification radiology receive recruited reduction reflect remodeling reported resolution response rotated scale score session several signed significance significantly simulated spectra spectral spectroscopic spectroscopy started statistic strength stress structural studied studies subjects suppressed suppression symptomatic tail taking treatment trend turnover undergo underpinning unsuppressed volume water weeks white women