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Abstract #0650

Quantitative Analysis of Pulmonary Inflammation After Endobronchial Allergen Challenge Using T1-Mapping MRI

Julius Renne1, Jens Hohlfeld2, Jan Hinrichs1, Christian Schnfeld1, Marcel Gutberlet1, Carla Winkler3, Cornelia Faulenbach2, Peter M. Jakob4, Norbert Krug2, Frank Wacker1, Jens Vogel-Claussen1

1Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany; 2Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany; 3Dep. of Pneumology, Hannover Medical School, Hannover, Germany; 4Experimental Physics (Biophysics), University of Wrzburg, Wrzburg, Germany

Endobronchial allergen challenge is an established method for the evaluation of new anti-allergic drugs. Today the concentration of eosinophilic cells is the standard readout parameter for pulmonary inflammation. Therefore repeated bronchoscopies are needed, which are a substantial burden for volunteers. A new method for identification and quantification of the pulmonary inflammation after endobronchial challenge using oxygen-enhanced pulmonary MRI (T1-mapping) is presented.

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Keywords

afterwards airway allergen allergic alveolar anti applications array aspects assessment asthma asthmatic audience back biophysics breath breathing burden calculation care cells challenge challenged channel clinical coil completed concentration control controls correlation covering cystic decrease dedicated defined derived detection develop developed diagnostic differed drugs enhanced equally establish established evaluate evaluated excluding experimental fast fibrosis flash fluid frank function furthermore future great healthy hold hours human incomplete inflamed inflammation inflammatory inspiration institute instructed invasive inversion last lavage local lung lungs magnitude mapping maps marked marker matrix median medical medicine monitor monitoring normally onto oxygen parametric patients peter physicists physics procedures prolonged protocol pulmonary quantitative quartile radiologists radiology rapid reaction reactions readout recovery registration repeated replacement requiring resp response rigid room safety school script segmentation segments self separately serve served serving shot significantly slice slices snapshot statistical stop stronger subjects substantial suggest target threshold tissue today torso transfer trials vessels visually volume volunteer volunteers