Meeting Banner
Abstract #0415

Simultaneous Spin Echo and Gradient Echo for fMRI Using the USPIO Agent Ferumoxytol in Humans: Enhanced Sensitivity and Potentials for High Resolution Mapping

Deqiang Qiu1, Thomas Christen1, Wendy W. Ni1, Heiko Schmiedeskamp1, Greg Zaharchuk1, Michael E. Moseley1

1Radiology, Stanford University, Stanford, CA, United States

In this paper, we present the study of the use of ultrasmall superparamagnetic iron particle (USPIO) for fMRI (termed ICE-BVI) using both gradient and spin echo methods. The contrast to noise ratio (CNR) of ICE-BVI was found to be of up to a factor of 3.8 higher than BOLD for gradient echo based method, and the gain is about a factor of 2 for spin echo based method. ICE-BVI has the potential of increasing robustness and accuracy for presurgical mapping and enhanced sensitivity in studying cognitive neuroscience.

Abstract PDF Presentation Video

Keywords

acceleration activated activation activities activity administered advantage agent amount approved audience auditory believed blood blue bold bottom brain cerebral channel christen clear coil columns comparing contrast correct courses covering custom decreases deficiency degree denote deviation dynamics echoes enhanced entire epochs even exists expect exponential fifth finger fits five fluctuation formed foundation full functional gain general gradient gray half head health hence hours human humans identify injection instructed intensity intravenously inversion iron larger largest linear mapping maps marker materials matrix measured minimally model models motion motor neural noise occurred ocular opens orientation original overlaid oxide oxygenation panel percentage pharmaceuticals physicists plot positive possibilities post presence previous processed prolonged protocol pulse radiology recovery refocusing registered related removed report resolution respect respective respectively respiratory response rest resting scale scanned scripts sensitive sensitivity series slice slices spin spoiled statistic statistics stays strong subject subjects substantially susceptibility tapping target task temporal tissue treating volume whether white