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Abstract #0212

Subcortical Volumetric Differences in Children with Sickle Cell Disease and Silent Infarction

Jamie M. Kawadler1, Jonathan D. Clayden2, Fenella J. Kirkham3, Christopher A. Clark2

1Imaging & Biophysics Unit, UCL Institute of Child Health, London, United Kingdom; 2Imaging & Biophysics Unit, University College London, London, United Kingdom; 3Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom

This work investigates for the first time specific subcortical structure volumes in children and adolescents with sickle cell disease, which has been shown to affect cortical grey matter and deep white matter.

Keywords

abnormalities accidents analyzed annals background basal behavioral bilaterally biophysics blood brain categorized cause cell central cerebellar cerebral child childhood children chronic classified cohort consistent control controls cooperative cortex cortical covariance decreases deep deficits delay described determine developmental diffuse disease driven east evidence findings flash focal frequently ganglia global greatest growth health hemisphere highly hypothesis hypoxia incidence infarction injury institute intelligence investigate journal kingdom kirk knowledge lesion lesions matched measures miller neurology palladium particularly patients pattern peaks pediatric pediatrics percentage picture post presence previous quotient race recent reduced reduction regionally relationship report reports represented retrospective reveal risk segmentations sibling sickle significantly silent sleeper specifically spectrum structure structures subject subjects subtle summarized support system thalamus thinning underlying unit variables visible vision volume volumes volumetric vulnerable white years