Meeting Banner
Abstract #0191

Quantification of Hepatic Blood Flow in Portal Hypertension Using 4D-Flow MRI: A Meal Challenge Study

Alejandro Roldn-Alzate1, Alex Frydrychowicz2, Oliver Wieben1, 3, Scott B. Reeder1, 3

1Radiology, University of Wisconsin, Madison, WI, United States; 2Radiology, Universittsklinikum Schleswig-Holstein, Lbeck, Germany; 3Medical Physics, University of Wisconsin, Madison, WI, United States

Portal hypertension is an end-stage complication of cirrhosis that leads to dramatic and complex alterations in the hemodynamics of the liver. Phase contrast 4D-flow MRI methods hold great promise to overcome the challenges associated with comprehensive non-invasive flow measurements in the abdomen. This study demonstrates the ability of radial 4D flow MRI to quantify changes in hepatic and mesenteric flow in patients with portal hypertension who are undergoing a meal challenge. Expect flow changes in portal venous, hepatic arterial and mesenteric vasculature were observed, including altered flow patterns, and flow in varices and the azygos vein.

Abstract PDF Presentation Video

Keywords

abdomen achieved acknowledge acknowledgments acquisition alterations alumni another aorta approved arrows arterial artery assess audience beck blood body bosh buffer challenge characterize circulation cirrhosis clinical coil collateral complex compliant comprehensive conditions conducted consent contrast coronary correlate coverage currently cycle decrease decreased described detail differed discovery done drainage dramatic elevated ensure entire evidenced excellent expected fasting flow form foundation gadolinium great hepatic hold hours hypertension identify importing included indicate induced informed ingested injected known laboratories lead least likely liver manual mapping masks materialize maximize meal measured medical mimics monitoring optimal overcome paired patient patients performance physics physiological placement plus portal post presence prior program promise quality quantification quantify quantitative radial radially radiology reeder resolution respectively response retrograde reversed segmentation segmented sensitivity shunt significance spatial stage staging started statistical statistically statistics studies subjects suitable summary superior support system target thank tool treatment trunk undergoing vascular vein velocity venous vessel vessels visualizations white years