Fast 3D Spiral Chemical Shift Imaging of Mitochondrial Metabolism in Brain with C6 Glioma Using Hyperpolarized [2-13C]Pyruvate

Keywords

acid acquisition administration aliasing allows altered although amount applied artifact assess audience avoiding balance bearing besides bicarbonate body brain brains built cancer catheter cells challenging chemical chosen clearly clinical coil conversion custom cycle days described detecting detection dirk dispersion displacement dissolved distributions echoes electrical enhanced entering excitation experiment exploited exploiting fast flux foundation full gift glutamate gradient hard healthy hemisphere implanted indicates infusion injected injection injections inner insert interleaves international investigate label labeled laboratory lactate larger latter lead least male maps marker matrix mayer measuring merchant metabolic metabolism metabolite muscle narrowed neurological normalized observation observe outside overcome overlaps oxidative oxygen park particular pathways permits post predominantly previously prior problem products program proposed proton pulse quantification radiology rats readout receive reduce reduced reflecting released response saline science selective sensitive simultaneous slice solution sparsity spatial spectral spectroscopic spin spiral start successfully suggested surface tail target therapies towards treatment tumor useful volume volumetric width