Meeting Banner
Abstract #3898

Characterization of Fe-Co Ferrite Nanoparticles for Contrast Generation and Heat Therapy in Cancer

Sheikh Manjura Hoque1, Yuegao Huang1, Samuel Maritim1, Daniel Coman1, Fahmeed Hyder1

1Yale University, New Haven, CT, United States

Ferrite nanoparticles are used for contrast, but they also have potential for cancer therapy because nanoparticles can be heated by alternating RF. Since diamagnetic resonances are susceptibility-shifted with nanoparticles, temperature and/or pH mapping with typical MRI/MRS methods are difficult. To generate both tissue contrast and map temperature/pH in presence of nanoparticles, we used a new method called BIRDS, which requires that we detect protons emanating from a temperature/pH probe (e.g., TmDOTP5-) itself, instead of the agents effect on water proton relaxation times. Promising in vitro results from a family of Fe-Co mixed ferrite nanoparticles are discussed.

Abstract PDF Presentation Video

Keywords

ability accurate achieved agent agents allow alternating although application appropriate become birds body broadened called cancer carried challenging characterization characterized chemical coated coating compartments composition compositions confirmed conjunction consideration contrast contrasted depicted detect deterrent deviation device diamagnetic diffractometer emanating enabling encapsulation encouraging energy enhancement example family ferrite fields finally formation generating generation goals gong grain haven heat heated highly human important increasing instead intensity interference investigation iron like magnetization mapping material materials mixed mixtures molecular moment much novel observe organs oxide patterns peaks phosphates potential precipitation presence probe probes property proton protons quantum quite radiation redundant reported requires scale sensitive significantly since song speed squid step strong structure superconducting susceptibility synthesis synthesized systems table temperature therapy thereby tissue towards typical ultra utilized various vitro water west widely yang