Meeting Banner
Abstract #3601

Cerebrovascular Reactivity Defect in Multiple Sclerosis

Yulin Ge1, Yongxia Zhou2, Hanzhang Lu3, Feng Xu3, Ilya Kister4, Hina Jaggi2, Damon Kenul2, Joseph Herbert5, Robert I. Grossman6

1Radiology, New York University Langone Medical Center, New York, United States; 2Radiology, NYU Medical Center, New York, United States; 32Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 4Neurology, NYU Medical Center, New York, United States; 5Neurology, New York University, New York, United States; 6Radiology, New York University, New York, United States

The cerebrovascular reactivity (CVR) may be impaired due to chronic and tonically higher level of nitric oxide (NO) secondary to the repetitive inflammatory activities in patients with multiple sclerosis (MS). This may lead to defective instantaneous oxygen supply to active neurons leading to chronic hypoxia and neurodegeneration. Using mild hypercapnia (mixed 5%CO2, 21%O2, and 74%N2) perfusion MRI at 3T MR, we found significant decrease of average global CVR of gray matter and normal appearing white matter in MS patients using psudo-continuous arterial spin labeling (pCASL) hypercapnia technique. This is the first study to measure CVR abnormalities in MS.

Abstract PDF Presentation Video

Keywords

abnormalities acquisition active activities activity advanced another appearing array arterial axial blood body brain breathing caffeine calibration capacity cellular cerebral channel chronic coil constant continuously contribute control controls decreased defect delay delivery detect devastating device diffuse dilatory disease disturb duration effective etiology excessive excluded exists exposure females flow function generated global gradient grant grants gray habituation head health healthy hematologic hours impaired impairment indicate indicating inflammatory label lancet larger leading lesions like likely loss maintaining males mapping maps materials matrix measure measured medical mild mixed motion national neurology neurons nitric observations occurs oxygen particularly patient patients percentage perfusion poorly preliminary previously prior process processes progressive quantitative radiology reactivity readout recorded recordings reduced reflecting regulating regulation relapsing repetitions represents respectively respiration response responsible room sclerosis score secondary selective separately series significantly slice slices smith southwestern stimulus studied subjects supply supported taken target technical thank tidal unit vascular volunteers whether white whole years