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Abstract #3599

7-Tesla GRE Imaging of Hippocampal Subregion Thickness Is Associated with Symptom Severity and Neurocognitive Deficits in Major Depressive Disorder

Tracy L. Luks1, Yan Li1, Angela Jakary1, Erin Gillung2, Natalie M. Holbrook2, Stuart Eisendrath2, Pratik Mukherjee1, Sarah J. Nelson3

1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; 2Langley Porter Psychiatric Institute, San Francisco, CA, United States; 3Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States

We used 7T MRI gradient-echo imaging to examine the thickness of 2 regions within hippocampal CA1, the cell-body layer stratum pyramidale (SP) and the synaptic layer stratum radiatum/stratum lacunosum-moleculare (SRLM) in Major Depressive Disorder patients, and to test the hypothesis that decreases in these ultra-high field MRI measures of hippocampal thickness would be significantly associated with increases in clinical symptom severity and deficits in memory and attention neurocognitive measures known to involve hippocampal function.

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Keywords

abnormality academic additional adjacent allows alone anatomy array assessed associations attention axis bioengineering biomedical body brain channel clinical coil connections control controls coronal correlated correlation correlations cortical decreases deficits degree depression depressions depressive digit discovery disorder emotional equipped errors examine field function general gradient grant head hypothesis identifies identifying indicated industry institute interference involve involved known layer learning linear longitudinal made major making matched matrix measures medical memory modality model nelson nova nucleus oblique oriented particularly partnership patients performance perpendicular porter psychiatric radiology rating receive reduced regulation repetitions scale scanned scanner sciences score scores severe severity side significantly sixteen slice slices span specificity stoop stratum subfield subfields subjects submitted subregion subregions supported symbol symptom symptoms synaptic therapeutic thicknesses trail transmit trials ultra verbal visible volume whole