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Abstract #3577

Integration of Functional and Structural Connectivity from rs-fMRI and DTI to Study Healthy Maltreated Adolescents

Minhui Ouyang1, Uma Rao2, Tejasvi Gundapuneedi1, Hao Huang1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Psychiatry and Behavioral Sciences, Meharry Medical College, Nashville, TN, United States

The underlying mechanisms of long-lasting impairments in behavioral, cognitive and social functioning caused by childhood maltreatment (MALTX) are not well-understood. Integrating functional and structural connectivity from resting state fMRI (rs-fMRI) and DTI provides insight of the affected brain circuits including both cortical region and white matter tracts in the maltreated subjects. In this study, rs-fMRI and DTI scanning were acquired from 19 MALTX adolescent volunteers and 13 age-matched control volunteers. We have identified disrupted structural and functional connectivity and revealed the relationship of the abnormal connectivity of both types in the maltreated healthy subjects.

Keywords

abbreviations abnormal abnormality abuse acquisition adolescent adolescents adults advanced adversity affected anisotropy audience behavioral brain clinical cluster clusters coefficient concurrently connectivity consistent cont control controls corpus correction correlated correlation cortex cortical cross cutoff datasets default detect detected development diffusion discovery disrupted emotional experienced family fibers filtered form fractional functional gradient hair healthy history identified identify indicated indicates indicating initiate integrated integrating integration knowledge known list maltreated maltreatment maps matched measures mechanisms medical might needed negatively neglect neurologists nonlinear occipital onset part participants pass personal physicists positive posterior potential power preceding prior processed psychiatric psychiatrists psychiatry psychologists psychopathology reconstructed reconstruction recruited registered relationship repetitions reports resolution respectively resting reveal risk scanned sciences scores seed sense serve sexual shot smith social socioeconomic southwestern space stage statistical status structural subject subjects substance suggesting suggests superior system table target template threshold traced tracts types underlying understood underwent upper volunteers vulnerability white widespread years yellow young