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Abstract #3576

Inhibition Network Differences Between ADHD and Healthy Adults Are Unbiased by Drug Use History

Jerod Rasmussen1, B.J. Casey2, Theodorus GM Van Erp1, Leanne Tamm3, Jeff Epstein3, Claudia Buss1, James Bjork4, James Swanson5, Tim Wigal1, Steven Potkin1

1UC Irvine, Irvine, CA, United States; 2Cornell University, New York, NY, United States; 3Cincinnati Children's Hospital, Cincinnati, OH, United States; 4NIH, Rockville, MD, United States; 5UC Irvine, Irvine, Ca, United States

Persons diagnosed with ADHD in childhood have a higher likelihood of substance abuse at a later age, adding a comorbid factor to attention network deficits brought on by the diagnosis. This work uses the largest sample to date to show that drug use frequency does not bias behavioral and/or cognitive differences when performing a Go/NoGo task. The sample size and multi-site nature of the study make these results especially generalizable.

Keywords

abuse account activation activity administered adolescents adults alcohol among analyses appetitive applied attention averaging behavior behavioral behaviorally brain buss calculating cannabis characterizes childhood children clear cognitive collapsed collapsing combined commission consisted content contrasts control corrected correction cortex cortical coupled criteria date deficit deficits derivative diagnosis diagnostic differential disorder disorders distortion drug either emotion emotional errors evidence excessive failure filter findings fixed frontal functional funded general history hyperactivity impacted impair impairment included individuals inhibit inhibition inhibitory inspection instructed inter interaction journal largest least literature local make manifested marijuana maturation month motion native network networks noted occipital omission onset participants pass past patterns performance planar play pole population previous primary prior project qualitatively randomized recruited registration related reported response responses risk runs sample science sites slice smith space spatial statistics status stimuli subject subjects substance suggested suggesting surface target task tasks template temporal terms therapeutic treatment variation varying ventricle walls washout whitening young