Meeting Banner
Abstract #3162

Fiberfox: A Novel Tool to Generate Software Phantoms of Complex Fiber Geometries

Peter F. Neher1, Bram Stieltjes2, Frederik B. Laun3, Hans-Peter Meinzer1, Klaus Hermann Fritzsche1, 2

1Medical and Biological Informatics, German Cancer Research Center (DKFZ), Heidelberg, Germany; 2Quantitative Image-based Disease Characterization, German Cancer Research Center (DKFZ), Heidelberg, Germany; 3Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

We present an interactive graphical tool, Fiberfox, to generate arbitrary fiber configurations and corresponding diffusion weighted images (DWI). The intuitive user interface allows for the generation of any number of straight, bended, crossing, kissing, twisting and fanning fiber bundles, simply by placing 3D-ROIs used as waypoints for the synthetic fibers. From these fibers, a DWI is calculated applying a user defined number of gradient directions, b-value, SNR, image size and spacing. Fiberfox is implemented in the open source medical imaging interaction toolkit (MITK) and will also be available as free download included in the next release of MITK Diffusion.

Abstract PDF Presentation Video

Keywords

abundance according added adjustment allow allows anisotropic application appropriate arbitrary artificial available biological bundle bundles cancer capabilities characterization combining commonly compartment compartments complex configuration configurations control crossing defined defining depicted described diffusion diffusivity discussed disease divided domain easily easy either employing enabling equally examples fanning fiber fibers firstly fourth fraction free generate generated generation generic geometries geometry global gold gradient graphical ground hardware helix highly hindered illustrate incorporate inform informatics inside integrated intensities intensive interaction interactive introduced intuitive kissing kurtosis labor limited local matrix medical model modeling models next noise novel open openly part paths peter phantom phantoms physics position positioned press process projects propagated property proposed providing quantitative radiology rank realistic reconstruction release requires restricted scalar secondly several shape shaped simulate simulated simulating software source splines step steps straight synthesis synthesize synthetic tangent task teem tend tensor tensors tissue together tool toolkit tools truth twisting twists water whole wide years