Meeting Banner
Abstract #3161

Large Deformation Diffeomorphic Metric Mapping for Unlabeled Curves: Application to Fiber Tract Bundles

Yung-Chin Hsu1, Wen-Yih Isaac Tseng1, 2

1Center for Optoelectronic Biomedicine, College of Medicine, National Taiwan University, Taipei, Taiwan; 2Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan

A registration method for unlabeled curves under the LDDMM framework is proposed, and this method is applied to register two right cingulum bundles for demonstration. The results show that the proposed method could effectively transform the tract bundles so that the global shapes are matched well. By registering the tract bundles to a common space, this method would be a valuable tool to investigate the brain morphology, which is a hot topic in neuroimaging studies in development, ageing or mental disorders.

Keywords

address analyses analyzed anatomical anatomies anatomy another application appropriate attempts attentions biomedicine brain bundle bundles categories category chin college common comprehensively concatenated contains cortical currently curve curves deformation demonstration dense detailed development discussed disorders divided dual effectively employed employing encounters ensure entire estimating even extended extension fact fiber field fields find flow fluid form formulation framework functional generalized geodesic getting global goal graduate gray head implementation impossible impractical indicating initial instead integrating investigate kernels knowledge known label lacks linear makes making mapping matches matching materials mathematical measure medicine mental metric mind minimizes models modified momentum morphology national norm object objects optimal optoelectronic overall pairing pairs popular potential practice prior problems proposed reconstructed reformulated register registered registering registration regularization richly roughly sciences several shape shapes smoothing space steps studied studies successes successful suggesting surface surfaces tail template term terms tool tract transformed treating turn unlabeled usually vacancy valuable varying vector volume white