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Abstract #2310

Effect of Metabolic Rate on Postocclusion Reactive Hyperemia in Rat Retina

Guang Li1, Jeffrey W. Kiel2, Damon P. Cardenas3, De La Garza H. Bryan4, Timothy O. Duong4

1Department of Radiology, UT Health Science Center at San Antonio, San Antonio, TX, United States; 2Department of Ophthalmology, UT Health Science Center at San Antonio, San Antonio, TX, United States; 3Department of Biomedical Engineering, UT Health Science Center at San Antonio, San Antonio, TX, United States; 4Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States

Reactive hyperemia and its modulation by varying metabolic demands have not been studied in the retina. We investigated the reactive hyperemia and hemodynamic reserve in the rat retina by measuring blood flow and oxygenation under dark, constant light and flicker. Our results showed that changes in metabolic rate by light conditions did not affect the reactive hyperemia likley because of the small BF reserve in the retinal circulation, suggesting that metabolic autoregulation in the retina is less able to compensate for increased metabolism.

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Keywords

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