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Abstract #2309

Effect of Occlusion Durations on Postocclusion Reactive Hyperemia in Rat Retina

Guang Li1, Jeffrey W. Kiel2, Damon P. Cardenas3, De La Garza H. Bryan4, Timothy O. Duong4

1Department of Radiology, UT Health Science Center at San Antonio, San Antonio, TX, United States; 2Department of Ophthalmology, UT Health Science Center at San Antonio, San Antonio, TX, United States; 3Department of Biomedical Engineering, UT Health Science Center at San Antonio, San Antonio, TX, United States; 4Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States

Reactive hyperemia has been attributed to metabolic local control in which BF is trying to match local metabolic demands. In the retina, reactive hyperemia and the effect of occlusion duration on reactive hyperemia have not yet been studied. This study used BOLD and laser speckle BF measurements to investigate reactive hyperemia after graded occlusion durations and probe the reactive hyperemia capacity reserve in the retina. We found that the retinal circulation is under metabolic control but it has smaller capacity for reactive hyperemia compared to other organs (i.e., brain, intestine, heart, etc).

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