Meeting Banner
Abstract #2235

Quantitative Measurement of Signal Fluctuations in ASL from Resting State Functional Networks

Weiying Dai1, Ajit Shankaranarayanan2, Gottfried Schlaug3, David C. Alsop1

1Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States; 2Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 3Neurology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States

We report quantitative measurement of signal fluctuation from resting state networks in volumetric arterial spin labeling (ASL) perfusion images of normal volunteers. Network fluctuations are much larger than residual noise. The combined signal fluctuation from all the networks is approximately 10% of the mean perfusion signal, but the signal fluctuation amplitude varies between the different networks. Unlike the residual noise, the resting state network fluctuations cannot be reduced by greater smoothing. Resting network quantification with ASL may be useful to further study the physiology of the fluctuations and may enable improved noise reduction and statistical analysis of ASL studies.

Abstract PDF

Keywords

access amplitude applied approximately arterial back bell beth blood bold brain capability cohort collected common components computation concatenation continuous contribution convert deaconess decomposed default demeaned dependent detect detected deviation difficult dimensional direct enable evaluate exact fluctuate fluctuated fluctuating fluctuation fluctuations formed function functional future global grand gray healthy important improved independent indicates individual input instead kernel kernels labeling laboratory larger largest lateral maps matrix measure medial median medical melodic mixing mode model motor much natl networks neural neurology nine noise open organized original oxygenation park perfusion physiologic physiology pixel preliminary preprocessed previously program protocol pulsed quantify quantitative radiology recently reduced reduction regional remained reported residual resting scale scaled scales scanner school science sensory separate seven smoothed smoothing software sources spatial spin spontaneous statistical steps stream structured studied studies subjects subtracting table temporal thirty understanding understudied units varies ventral visual volume volunteer volunteers widely years