Meeting Banner
Abstract #2142

Correlation of Imaging Connectivity with Electrophysiological Connectivity Using Intracranial Electrodes

Stephen Jones1, Erik B. Beall2, Jorge A. Gonzalez-Martinez1, Blessy Mathew1, Dileep Nair1, Imad Najm1, Michael Phillips1, Ken E. Sakaie1, Myron Zhang1

1Cleveland Clinic Foundation, Cleveland, OH, United States; 2Cleveland Clinic, Cleveland, OH, United States

We study the correlation between diffusion weighted imaging (DWI) measures of structural brain connectivity and electrophysiological connectivity obtained from intracranial electrodes in epilepsy patients. We have collected data from four patients, each with around 150 electrode contacts implanted, and our analysis suggests that the correlation between DWI-based connectivity and electrophysiological connectivity is only modest and still uncertain, which may shape how we interpret DWI data and results.

Keywords

accuracy activity although always anatomic attempt audience believe brain causes clinic clinical combined comparing component compute computers concordant connection connections connectivity conner contact contacts correlate correlation cortical deep density derive developed diffusion diminish direct directly discordance distance either electrical electro electrode electrodes electroencephalography epilepsy evaluated every evidence evoked explored extensive extensively fast fiber find foundation fully functional functionality gold grid human implantation implanted implementation include included incompatibly indicate indicates infer inherent intrinsic known language lead little logical major many maps measure measures measuring medicine methodology mild minimal modest necessarily neural pair pairs parallel path pathways patient patients physiologic physiology plot poor positions potential presumed prior probabilistic procedural question reasonably record recording recordings regarding relation relevance reported represents resolution response resting scatter solid space square still stimulate stimulated stimulating stimulus strong structural supporting surgically system taken target today toward tracking tract trend uncertain understood underwent variations various varying versa visa whereby white