Meeting Banner
Abstract #1945

Neurochemical Changes in Rat Brain After 5-Fluorouracil Chemotherapy Assessed by 1H MR Spectroscopy at 9.4 T

Ryutaro Nakagami1, 2, Masayuki Yamaguchi1, Yoshifumi Abe3, Tatsuhiro Hisatsune3, Akira Furukawa2, Hirofumi Fujii1

1Division of Functional Imaging, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; 2Graduate School of Health Sciences, Tokyo Metropolitan University, Arakawa-ku, Tokyo, Japan; 3Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan

Recent studies have reported that some cancer patients who received chemotherapy experienced mild cognitive impairment. Although the mechanism of this type of cognitive impairment is not fully understood, preliminary studies suggested that chemotherapy may induce neurotransmitter deficits, damaging cognitive function. Investigation of brain metabolite changes using in vivo MR spectroscopy may help to understand the mechanism of chemotherapy-induced cognitive impairment. In this study, we assessed metabolite changes in the brains of rats that received 5-FU (100 mg/kg) chemotherapy using 1H MR spectroscopy at 9.4 Tesla.

Abstract PDF

Keywords

acid acquisition addition administered alanine animal animals approved array assessed assigned axial behavior behavioral brain brains breast cancer cancers carried cells chamber chart chemotherapy choline circles cognitive coil combination committee concentration concentrations conditioning consecutive contextual control correlation damage days detect division dose electric equivalent evaluated experimental fear fellows field foot freezing functional gastric glutamate graduate grant health human impairment in vivo indicate induced injection injections injure institutional intervals intravenous investigation japan lactate larger length male materials matrix measured mechanisms memory metabolite metabolites metropolitan next nine occur owing patients percentage period placed plot position possibly preliminary press previous produce prolongs promotion protocol quantify randomly rapid rare rats received recurrence reduced reduces reduction regimen related reported resolved respectively risk saline sample scanner school science sciences seem session sessions shocks significantly society spatial spectra spectroscopy statistically student studies suspect system systems tail tone training treated treatment underlying understand underwent unknown version video view volume weighing yellow