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Abstract #1944

Age-Related Metabolite Alterations in Adolescents with High Functioning Autism, an 1H-MRS Study

Evelien M. Barendse1, Albert P. Aldenkamp1, Roy PC Kessels2, Marc P.H. Hendriks2, Geert Thoonen1, Paul A.M. Hofman3, Walter H. Backes3, Jacobus F.A. Jansen3

1Epilepsy Centre Kempenhaeghe, Heeze, NB, Netherlands; 2Neuropsychology, Radboud University Nijmegen, Nijmegen, Ge, Netherlands; 3Radiology, Maastricht University Medical Center, Maastricht, Li, Netherlands

In this cross-sectional study, we investigate the effect of age and intelligence on occipital metabolite concentrations in adolescents (aged 13-19y) with high functioning autism (HFA) and healthy controls. We observed that 1H-MRS provides evidence of atypical membrane metabolism development in HFA, which potentially underlies the observed atypical behavioral development in autism.

Keywords

abnormal abnormalities according additionally adjacent adolescents aged alterations altered analyzed arbitrary attending atypical audience autism behavioral blue bounds braces brain category cellular child children choline chosen clinical clinically concentration concentrations considered control controls coronal cross dashed decrease decreases dependent development developmental diagnosed dimensional disorder disorders edition epilepsy evidence exceeded excellent excluded existence field function functioning glutamate green healthy heterogeneous impaired include included independent indicate indicating indicative intelligence involved kindly known linear lobe located macromolecule male matched matrix measure medical membrane metabolic metabolism metabolite metabolites neurology occipital oral peaks pervasive phosphate populations potential potentially press previous previously processing psychiatry quality radiology recorded regression regular related remoteness repetition reported reports respectively revealed rump scale scanner school secondary sectional simulated slices spectra spectral spectroscopy spectrum statistics subjects suggest suggested suppression syndrome target third transl trend trends turnover typically unclear underlies underlying underwent units unsuppressed vapor variables version visual water wear yellow yield yields younger