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Abstract #1204

Chronic Exposure of Neurotoxic Doses of D-Amphetamine Potentiates the Central Effect of an Acute Challenge with Methylphenidate.

A. Schrantee1, 2, J.L. Tremoleda2, M. Wylezinska-Arridge2, W. Gsell2, L. Reneman1

1Academic Medical Center, Amsterdam, Netherlands; 2MRC Clinical Sciences Centre, Biological Imaging Centre, London, United Kingdom

This study assesses whether phMRI is a valid tool to study the sensitivity to study moderate DA dysfunction. To this end we administered dAMPH chronically and assessed the BOLD response to a MPH challenge.

Keywords

able abnormalities academic acquisition activation activity acute addition administered amphetamine anatomical animal animals apart array artery assess assessments atlas biological blood blunted bold brain brains buffer central challenge chronic clinical cluster clusters coil coils contiguous contrast contribution control controls coronal corp corrected cortical decrease determined diagnostic differ diminished direct dopamine doses drive drug drugs dummy dysfunction expected experiment exposure fast feat femoral fifty fixed function gems gradient hypothesis indicate indicates induce induced injection inner intensity interaction interleaved investigate loss male mapping matrix mechanically medical minutes mixture mode model monitoring neurons ongoing oxygen parametric part perfused perfusion pharmacological phosphate pinpoint placed position positive pressure rather rats receive received receptor reflects regardless repeated response revealed river saline sciences sensitive sensitivity series significance significantly slice slices spatially statistic subsequent subtle subtypes suggest surface system systems template threshold thresholded tool train transmit transporters treated treatment triggered unclear underlying unilateral ventilated version volume washout whether zero