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Abstract #1202

Abnormal Spontaneous Brain Activity in Drug-Nave, First Episode Depression: A Resting-State fMRI Study

Hong Yang1, Manli Huang2, Qidong Wang1, Zhan Feng1

1Department of Radiology, First Affiliated Hospital of College of Medical Science, Zhejiang University, Hangzhou, Zhejiang, China; 2Department of Psychiatry, First Affiliated Hospital of College of Medical Science, Zhejiang University, Hangzhou, Zhejiang, China

Using ALFF approach, we are to test the hypothesis of the abnormal neural activities in the prefrontallimbic networks in drug-nave, first episode depression. Twenty-three patients and twenty controls were recruited. Twenty-two axial slices covering whole brain were acquired. Data processing was performed using DPARS software. Compared to controls, a significant increased ALFF in right frontal lobe and a significant decreased ALFF in right cerebellum, right occipital lobe as well as right parahippocampa gyrus were showed in patients. The abnormal neuronal activity in resting state support a model of dysfunction in the prefrontallimbic networks in first episode depression.

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Keywords

abnormal according activities activity affiliated amplitude analyses anterior array assistant axial band bars behavior biological bipolar blue brain calculation cerebellar cerebellum channel china cognitive coil college connections connectivity considered control controls correction correlate cortex covering criterion decreased deficits depression diagnostic disrupted dividing drug dysfunction eight emotional episode existing experiencing explaining females filtering findings fluctuations frequency frontal functional global head hong hospital hypothesis included indicates involved limbic linear lobe local long make males matched matrix maybe meanwhile medial medical model molecular monitor mood motion networks neural neuron neuronal normalization occipital opposite pass patient patients posterior potential power preprocessing processing progression properties psychiatry radiology recruited regulation related removing report resting root sample scanner science score series seven side simplicity sixteen slice slices smoothing software spatial spectrum spontaneous square standardization structures superior support timing tonsil tool trend twelve twenty unclear volumes whole yang yellow