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Abstract #0542

High Spatial and Temporal Resolution Dynamic Contrast-Enhanced Magnetic Resonance Angiography (CE-MRA) Using Compressed Sensing with Magnitude Image Subtraction

Stanislas Rapacchi1, Fei Han1, Yutaka Natsuaki2, Randall Kroeker3, Adam Plotnik1, Evan Lehrman1, James Sayre1, Gerhard Laub, J. Paul Finn4, Peng Hu4

1Departement of Radiology, UCLA, Los Angeles, CA, United States; 2Cardiovascular, Siemens Healthcare, Los Angeles, CA, United States; 3Siemens Healthcare, Winnipeg, MB, Canada; 4Departement of Radiology, University of California Los Angeles, Los Angeles, CA, United States

We propose a compressed sensing technique based on magnitude image subtraction for high spatial and temporal resolution dynamic contrast-enhanced MR angiography (CE-MRA). In a breath-held CE-MRA acquisition, the subtraction of a pre-contrast mask to a post-contrast image promotes sparsity of the difference image. This "subtraction-sparsity" has been previously reported and our proposed magnitude subtraction-based technique takes advantage of this sparsity while avoiding a number of issues with direct k-space subtraction. Full-sampled Cartesian 3D CE-MRA datasets were retrospectively under-sampled and different strategies of reconstruction were evaluated. Our technique was tested with a prospectively under-sampled CE-MRA sequence achieving an acceleration of 12.5x.

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Keywords

accelerated acceleration according accurate acquiring acquisition allows although anatomical angiography applicable applications arterial audience avoid benefit breath capable cardiovascular chest clinical clinicians close color combined combining comparing complex compressed confirmed context contrast coronal datasets defined degradation details develop developed direct dynamic enabled enabling enhanced equations evaluated even every excellent extended extensions feasible fidelity fine five fold footprint frames full general goal good held highly hold improved independent indicates individual inferior injection instead integrates iterative loss magnitude mask minimization noise norm novel original parallel poor post potential practice previously promotes propose proposed prospective prospectively providing qualitative qualitatively quality quantitative quantitatively radiology random reconstruction reconstructs remain resolution retrospective retrospectively sampled sampling scientists scores sensing separate sharing short shorter significantly slice solving space sparsity spatial split strategies structure subtracted subtraction successive suffers superiority taking target temporal term thick thin third tissue transit transverse twist useful various vascular venous view volume volumes volunteers windowing zoomed