Meeting Banner
Abstract #0346

Morphological Standards for the Human Spinal Cord Validations and Preliminary Applications to Patients

Virginie Callot1, Lo Fradet2, 3, Jean-Philippe Ranjeva4, Guillaume Duhamel5, Olivier M. Girard4, Pierre-Jean Arnoux2, Yvan Petit3

1Centre de Rsonance Magntique Biologique et Mdicale (CRMBM, UMR 7339), Aix-Marseille University, Marseille , France; 2Laboratoire de Biomcanique Applique (LBA, UMRT 24), IFSTTAR / Aix-Marseille Universit, Marseille, France; 3Department of Mechanical Engineering, cole de technologie superieure, Montreal, Quebec, Canada; 4Centre de Rsonance Magntique Biologique et Mdicale (CRMBM, UMR 7339), CNRS / Aix-Marseille Universit, Marseille, France; 5Centre de Rsonance Magntique Biologique et Mdicale (CRMBM, UMR 7339), Aix-Marseille University, Marseille, France

The objective of this study was to investigate SC morphological statistical differences (intra/inter-individual, age, sex, postmortem/in vivo) and to provide invariant features of the complete in vivo human normal spinal cord that may serve as database for individualized study of SC pathophysiological conditions, either for clinical practice and prognosis evaluation or to establish an accurate model of the SC that will open new perspectives to study compressive mechanisms such as encountered in SC injury or spondylotic myelopathy.

Keywords

absolute accurate aged already application applications audience axial biases border build canal care cervical characterization clinical comparing complete compressive conditions conducted considered context control cord correlations cross database decrease decreased depicted derived described diagnosis either encountered engineering entire equal errors establish evaluate evaluated example except exist expected extrapolate features female finally fixation fully gait geometry good healthy help human hypothesis illustrated impairment in vivo included individual individualized influence influences injury inter intra invariant invariants investigated investigation jean leave limiting locally longer mainly material measured mechanical mechanisms model modeling models moreover morphological morphology normalized observations offered older open particular pathological pathologies patient patients people person perspectives postmortem potentiality practice predictive preliminary prognosis progression proportion proportions protect quality real reduced reported represent resolution resp respectively risk score segmented semi sensory shrinkage significantly situation situations slice slices spastic spinal spine squared statistically studies subject surface surgical synchronization taken target term trends validations variations vertebral volunteers young