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Abstract #0344

Layer-Specific Manganese-Enhanced MRI of Diabetic Rat Retinas Associated with Light and Dark Adaptation at 11.7T

Bryan H. De La Garza1, Charkradhar Velagapudi2, Hanna E. Abboud2, Guang Li3, Timothy O. Duong4

1Ophthalmology/Radiology , Research Imaging Institute, Univ. of Texas Health Science Center at San Antonio, san antonio, tx, United States; 2Division of Nephrology, Department of Medicine, Univ. of Texas Health Science Center at San Antonio, San Antonio, tx, United States; 3Ophthalmology/Radiology, Research Imaging Institute, Univ. of Texas Health Science Center at San Antonio, san antonio, tx, United States; 4Ophthalmology/Radiology, UT Health Science Center at San Antonio, san antonio, tx, United States

This study used high-resolution manganese-enhanced MRI (MEMRI) to investigate the manganese uptake in different layers of the retina of diabetic retinopathy (DR) rats under light and dark adaptation. In normal rats, dark adaption lowered inner retina MEMRI activity, increased outer retina activity, and did not affect the choroid compared to light adaptation. In DR rats compared to controls, MEMRI revealed significant reduced Mn uptake in all three (inner, outer, and choroid) retinal layers. Differential reduced MEMRI activity in the dark in the outer layer in DR rats compared to control animals, suggesting outer retina dysfunction at early DR.

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Keywords

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