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Abstract #0338

Rapamycin Treatment Ameliorates Brain Metabolite Levels After Transient Focal Ischemia in Rats

Anjali Chauhan1, Uma R. Sharma2, Naranamangalam R. Jagannathan2, Y. K. Gupta1

1Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India

Rapamycin is shown to afford neuroprotection in animal models of neurological disorders. We have previously demonstrated neuroprotective potential of rapamycin in middle cerebral artery occlusion (MCAo) model of stroke. The present study was undertaken to study the biochemical changes after MCAo and also evaluate effect of rapamycin on MCAo injury. We observed increased Lac and decreased Gln/Glu, Cr/PCr, GPC/PC, mI, NAA, Tau and GABA in vehicle group as compared to sham group. In rats treated with rapamycin, decreased Lac and increased Gln/Glu, Cr/PCr, GPC/PC, mI, NAA, Tau and GABA was observed in MCAo rats, suggesting to protective mechanism of rapamycin.

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Keywords

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