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Abstract #4449

Brain Biochemical Abnormalities and Cognitive Impairments in Patients with Type 2 Diabetes and Major Depression: A Combined 1H-MRS and Neuropsychological Study

Shaolin Yang1, 2, Olusola Ajilore1, Melissa Lamar1, Laura Korthauer1, Anand Kumar1

1Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States

Type 2 diabetes and major depression are mutual risk factors. Previous studies have evidenced brain biochemical abnormalities in cortical and subcortical regions as well as cognitive deficits in patients with either disease alone or both. In order to better understand the pathophysiological mechanisms of these disorders, we examined whether brain biochemical abnormalities measured through 1H magnetic resonance spectroscopy are correlated with cognitive function and performance and whether there is any difference in the correlation profiles among these diseases.

Keywords

abnormalities adult alone among analyses analyzed anterior assessed association attention backwards battery better biochemical brain category choline circuits clinical clinics cluster coding cognitive combination combined community composite compounds concentration concentrations conducted consistent consistently containing control controlling controls correct correlated correlation correlations cortex cortical covariance delay delis depression determine determined deviations diabetes diagnosis digit disease diseases domain domains edition education either elevated errors evaluation examined executive finding findings five free frontal function head healthy impairment impairments included index intelligence interference interview laboratory language learning linked listed local logical long major making measured memory metabolite metabolites mutual needed negative negatively nucleus partial patients patterns percent performance placement processing psychiatric psychiatry quantification radiology reasons recall recent record recruited reflected relevant report reported reproduction respective respectively reversed review risk sample scale scanner score scores self significantly spectral statistical subject subjects switching symbol system task trail trials type unsuppressed verbal visual water whether white word yang