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Abstract #4448

Interferon-Alpha Induced Metabolic Alterations in Basal Ganglia and Anterior Cingulate Cortex

Xiangchuan Chen1, Reena Anand2, 3, Xiaoping Hu1, Ebrahim Haroon2, 3

1Biomedical Imaging Technology Center, Emory University, Atlanta, GA, United States; 2School of Medicine, Emory University, Atlanta, GA, United States; 3Winship Cancer Institute, Atlanta, GA, United States

Metabolic alterations induced by chronic administration of interferon (IFN)-alpha for the treatment of hepatitis C virus infection were examined with single voxel magnetic resonance spectroscopy. The results showed that the metabolisms of glutamate, myo-inositol and choline in the anterior cingulate cortex, left and right basal ganglia were altered by the treatment with IFN-alpha. These metabolic changes in the abovementioned brain regions may be the underlying mechanism for the behavioral alterations (e.g., depression) induced by the treatment.

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Keywords

activation active administration alpha alterations altered analyzed another anterior award bars basal behavior behavioral biological biomedical brain cancer central choline chronic collected college concentration concentrations conditions control correlated correlating cortex depression discontents disorder divided error excluded exhibited fatigue formerly foundation functional ganglia glucose glutamate hepatitis hypothesis hypothesized impact improve induced infection inflammation inflammatory influences institute intake interaction interferon interval investigated investigations investigator larger major marginally mechanisms medical medications medicine metabolic metabolism metabolisms metabolites might miller nervous neural official outcomes participant participated patients pattern patterns press primary procedure processing psychiatric psychiatry psychotropic publication reported respectively role sample sampling scanner school session sessions solutions spectroscopy structural support supported symptoms system technology therapy treated treatment trio twenty underlie underlying understanding underwent unstable virus waiting week young