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Abstract #4441

T2 MR Relaxometry Study of Acute Heat Stress Induced Changes in Rat Brain at 7T

Sunil Koundal1, Sonia Gandhi1, Rajendra P. Tripathi1, Subash Khushu1

1NMR Research Centre, INMAS, Delhi, India

Hyperthermia associated with heat stroke is a life threatening illness inducing CNS dysfunction, such as delirium, convulsion and coma. Heat stress induces neurotoxicity in brain caused due to oxidative stress resulting in neuronal cell degeneration. Present studies investigate changes in T2 relaxation on heat exposure & possible tool to track neuronal cell damage. There is a significant decrease in T2 values for hippocampus & thalamus regions due iron or reactive oxygen species accumulation on heat exposure which might reacts with lipids, proteins, DNA causing lipid peroxidation, altered protein conformations, & apoptosis. These studies will be useful in non-invasive tracking & evaluation of neuronal cell degeneration due to heat stress at an early stage.

Keywords

acclimatized accumulated accumulation acute adaptive affects almost alters anion antioxidant back beyond brain cages caused causes causing cell cent central certified check chow concentration control controlling converts convulsion correlation cortex customized cycle damage death decay decrease degeneration deposition development developmental diffusion dysfunction enhance enzyme evaluation examined exponential exposure expression extending fact field fold forms free gene give heat heme humans hypothalamus important indicating induced induces induction inhibition inhomogeneities initiation insight invasive iron lead leads lipid lipids literature local many materials matrix monoxide necrosis nervous neuronal neurotransmitters nitric oxidative oxygen particularly pathways performance permanent peroxide physiological placed plays possibly post powerful previous problem programmed proteins pulse radical rare rats reactive reacts recovery regarding regulated reported resolution respectively response role room selected severe similarly slice slow software species spectroscopy stage strength stress stroke studies system table temperature thalamus thereafter thermal tissue tool trace tracking treated treatment triggering understand univ useful various week wide