Meeting Banner
Abstract #4420

In Vivo Potassium-39 MRI at 9.4 Tesla Using a Room-Temperature Surface Resonator: Does Cryogenic Cooling Help?

Ibrahim A. Elabyad1, Friedrich Wetterling1, Nagesh Shanbhag2, Lothar Schilling2, Lothar R. Schad1

1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 2Pre-clincial Neurosurgery Department, Heidelberg University, Mannheim, Germany

In the current feasibility study, a single-tuned 39K surface resonator was developed and tested for the measurement of 39K signal in the normal live rat brain. Compared with the previous published results, the herein used CSI technique in conjunction with improved resonator sensitivity achieved approximately 5 times higher SNR in half the acquisition time. Additionally, the S/N improvement by cryogenic cooling the resonator was estimated from simulated copper RF-coil at room-temperature (RT) of 293 K and cryogenic temperature (CT) of 90 K. For both coils, full-wave Electro-Magnetic (EM)-simulations were computed for a single loop resonator with 35-mm diameter and 1.5-mm wire thickness for unloaded and loaded conditions. Results show that, 2.3-fold sensitivity improvement is expected when the coil is cooled down to 90 K, which could further improve the available signal in future 39K-MR imaging studies of the rat brain at 9.4T. In conclusion, 39K-MRI of the rat brain is possible at 9.4T using a CSI sequence and a single-tuned surface resonator and 39K resonator sensitivity can be further improved by cryogenic cooling.

Abstract PDF E-Poster Video

Keywords

achieve achieved acquisition adult advantageous analyzer approval arranged assisted assumed available axial bandwidth birdcage bottom brain capacitors chemical circuits clinical coil coils column combined compartment computed concentration conditions connected cooled cooling copper coupling cryogenic decouple described developed diameter direct distance double edge electro elsewhere ethics evaluated exchange experiment extracellular filters fixed flash fold form frequency full furthermore geometrically hand head help hence herein impedance improve improved improvement in vivo inductive input inter intracellular irreversible license live load loaded local loop loss losses matched matching materials measured micro monitoring much narrower nearly network nevertheless nitrogen noise occurs orthogonally pathological phantom potassium previously prototype proved quality quantum radio reagents real recent resistance resolution resolutions resonant resonator resonators return revealed room sample schilling sensitivity setup significantly simulated simulation simulations since slice sodium spiral steady stroke structures studies suffers superimposed surface system temperature temperatures tissue triple tune tuned tuning unloaded variable vector view wave wire written zero