Meeting Banner
Abstract #4399

The Influence of Template Metabolite Omissions on 1H-MRS Quantification

Reggie Taylor1, 2, Peter Williamson, 13, Jean Thberge, 12

1Medical Biophysics, University of Western Ontario, London, ON, Canada; 2Medical Imaging, Lawson Health Research Institute, London, ON, Canada; 3Psychiatry, University of Western Ontario, London, ON, Canada

Many metabolites contribute to the area in a 1H-MRS spectrum, but not all are accounted for in every basis set. If they are not included in the basis set, their area may likely lead to an error in another metabolites concentration estimate. The purpose of this study was to systematically identify which metabolites compensate for a metabolites area when it has been omitted from a fitting template using Monte Carlo simulations. Every metabolite studied, with the exception of lactate, lead to an error of at least 10% in another metabolites concentration estimate when it was omitted from the template.

Keywords

absence account accounted added affected allowing altered avoid basis biomedical blood brain broadening chain characteristic chemical choline complicated components concentration concentrations conduct constants constraint constraints contributions contributors coupling demonstrating despite determined direct done easily efficiently electron empirically environment equivalent errors estimation estimations even every examine example expected field fitting flow fluctuation fluctuations full global glucose greater heavily house identified illustrate importance improves in vivo included inclusion incorrect indicating individual influence influenced influencing influential interpretation jean largest least limitations limited literature local made making mandatory medical metabolite metabolites minimize next noise nuclei often omission omissions omitted omitting overlap pattern peak peaks peter pharmaceutical placed poor poorly preserve psychiatry quality quantification quantified quantify rather relatively reliability relies remaining represent residual resonate respectively sample shielding signature signatures simulated simulation simulations software somewhat spectra spectral spectrum spreadsheet squares steam strength strengths successively sufficiently suggests suite summarized surprisingly systematically table template templates typically unaccounted usually utilizes variation western