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Abstract #4398

Quantification of Cervical Tumor Choline Concentration by Proton MR Spectroscopy at 3 Tesla: A Pilot Study

Yao Ding1, Roderick McColl1, Ralph Mason1, Robert Sims1, Jayanthi Lea1, Paul Weatherall1

1Radiology Department, UT Southwestern Medical Center at Dallas, Dallas, TX, United States

In Vivo 1H-MRS is a non-invasive technique that provides information on tumor metabolism, which may be used in tumor diagnosis and tumor response to therapy. Recently, several studies have demonstrated that Cho can be detected in human cervical tumors using 1H-MRS at 1.5 T. However, in some of these studies, Cho signals were also detected in post-treatment residue tissues and in normal cervix tissues. Thus, a quantitative method is necessary for quantifying the accurate levels of Cho for differentiating between different pathologies. The current study applied an internal water reference method to investigate the absolute quantification of Cho levels in cervical tumor system. We hope 1H MRS can be used to improve diagnostic accuracy and monitor cervical cancer response to therapy.

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Keywords

absolute accounting accuracy accurately adjacent analyzed applied believed best biopsy cancer carcinoma care cell cervical cervix choline clear clinical coil combination complete completion concentration consistent constant content correction correlation decrease decreased detected determine diagnosis dimension ding disappeared done equation evaluation examination example exams fitting foundation gain healthy hence human hypothesis illustrates implementation improve in vivo included indicative integral internal invasive lipid localization located magma magnified measured medical metabolism molecule monitor monitoring months necrosis noted nuclei obvious paired pathologies patient patients peak pilot placement positive post predictive press prior produces proton proven quantification quantitative radiologist radiology radiotherapy receiver recently recorded reduced reduction referencing relatively representative residual respectively responder responders response sample segregate several significantly software southwestern spectral spectroscopic spectrum squamous start strategy studies subjects subsequent substantially supported suppressed surface system systems table therapy tissue tissues treated treatment treatments tumor tumors undertaken units unsuppressed utilized utilizing visible volunteer water weeks whether width year years zones