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Abstract #4388

Direct Measurement of Pyruvate T1 in vivo and the Effect of Blood Oxygenation

Samira Kazan1, Steven Reynolds2, Jo Bluff1, Aneurin Kennerley3, Emily Wholey4, Jason Berwick3, Vincent Cunningham5, Martyn Paley2, Gillian Tozer1

1Oncology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom; 2Human Metabolism, University of Sheffield, Sheffield, United Kingdom; 3Psychology, University of Sheffield, United Kingdom; 4Institute of Cancer Research, London, United Kingdom; 5Aberdeen Biomedical Imaging Centre, University of Aberdeen, Scotland, United Kingdom

 

Keywords

absolute addition administered affect aliquot allow animal animals applied aqueous arterial artery artificial assumed atropine automated bearing biomedical blood bluff body bore cancer cell chamber compatible conclude conditions constant containing conversion correlation cradle custom decay decaying delivered delivery determine developed direct dosed drawn drugs dynamic established exam femoral fits fitted flow full gaseous halted heart heat human hypo hypoxia induction influence infusion inhalation injection injector input institute intravenous inversion investigated kinetic king kingdom know lactate listed living local magnet maintained maintenance male marker measured mixture models monitored moral novel nuclear observable oncology oxford oxygen oxygenation paired physiological place placed polarization polarized positive prepared pressure prob probes production pulse pump quantification rats recovery rectal regarding required resp respiratory robust saturation select sensing sensitive separate separately shortening slice solution south spectrometer statistically strong substrate surface system systemic table takes taking temperature tissues together trend tumor variation various vein versus vessel ween withdraw withdrawal