Qualification of in vivo 1H MRS as a Quantitative Preclinical Tool for Evaluating Drug Efficacy in Pharma Research

Keywords

achieved acid acting alleged alpha anesthesia animals appropriate assessed available basil biochemistry biologically biomedical bird body brain breathing bridge cage carried cerebral circularly clinical coil comprehensive conditions consistent continuous correspondingly corroborated currently date demonstrating dependent detected detects determined differential direct directly discriminating discriminative disease disorders distinct domain dose doses drug efficacy elicited engineering equipped essence establish excitation exposure findings former functionally generic glutamate goal heterogeneous highly in vivo incongruous incorporated indirect indirectly induced inhibitor input institute interleaved intervention interventions irreversible literature medial metabolism metabolite missing moderate modulation monitoring moreover mostly neurons neurotransmitter neurotransmitters numerous outcomes outer particularly pharmacological pharmacologically plasma polarized pool pools power press projected prospective psychiatric qualification quantification quantifications quantitative rats readily readout receiving reception regulation relationships relevance relevant reliable represent reproducible resolve respectively response routine routinely samples scanner sensitivity setups specificity spectra spectroscopy studies suppression surface system targeted testify tool treatment tripartite unpaired upon vapor vehicle volume water width yields