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Abstract #4362

MRI of Intracoronary Local Delivery of Motexafin Gadolinium: Towards Molecular MRI-Guided Gene Therapy

Yanfeng Meng1, Jinnan Wang2, Jihong Sun1, Feng Zhang1, Patrick Willis1, Jiakai Li1, Han Wang1, Tong Zhang1, Stephanie Soriano1, Bensheng Qiu1, Xi

1Radiology, University of Washington, Seattle, WA, United States; 2Clinical Sites Research Program, Philips Research North America

This study was to develop a new technique, using molecular MRI to monitor local agent delivery to coronary artery walls for potential MRI-guided prevention of in-stent restenosis. The study was divided into three phases. For the In Vitro confirmation, we determined the optimum dose of Motexafin Gadolinium (MGd), a multifunctional intracellular T1 MR contrast/anti-atherosclerotic agent. For ex vivo and in vivo study, we infused MGd/trypan blue the coronary arterial walls under MRI, which were correlated with histology confirmation. This study initially demonstrates the possibility of using MRI to monitor the local agent delivery and distribution in the coronary arterial walls.

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Keywords

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