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Abstract #4335

Hexamethyldisiloxane-Based Dual-Modality Dual-Functional Nanoprobes for Cellular and Molecular Imaging

Jyothi Menon1, 2, Praveen Gulaka1, Madalyn McKay2, Sairam Geethanath1, Vikram D. Kodibagkar, 13

1Joint program in biomedical engineering, UT Arlington/UT Southwestern Medical Center, Dallas, TX, United States; 2Radiology, UT Southwestern medical center, Dallas, TX, United States; 3School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States

An emerging need for evaluation of promising cellular therapies is a non-invasive method to track and image the movement and health of cells following transplantation into the subject. Multi-modal imaging strategies are becoming more popular in recent times because of their improved sensitivity, higher resolution and structural/functional visualization. This study aims at formulating hexamethyldisiloxane (HMDSO) based dual modality (MRI / Fluorescence), dual-functional (oximetry/detection) nanoprobes for cellular and molecular imaging. Studies using CRI Maestro and PISTOL imaging confirmed that these nanoprobes could be used to detect changes in oxygen tension and for fluorescence imaging.

Abstract PDF E-Poster Video

Keywords

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