Simultaneous 13C MR Spectroscopy Measurements of Hyperpolarized [1-13C] Pyruvate in Two Cancer Bearing Mice

Keywords

accurately acquisition addressing adherence administered allow amount anatomical animal animals appear appearance applications approximately assignments attributed avoid band bearing biomedical blood bock bolus brindle buffer cancer carried cells characterized coil colon combination commonly comparable compound compounds concentration concept conditions containing context contribution contributions conversion cycling days delay diameter efficient enabled enables enhances enzyme essentially evolution example excitation expanding experiment feasibility field fitted fitting flash heterogeneity horizontal identical in vivo indicated indicating inferior injected injection interference intravenously introduced label laboratory lactate lasted little make many metabolism mice minutes mixture monitoring mouse nude organs oxygen parallel particular peak pharmacology polarization polarized polarizers position press principle problem profiles proof proton pulse puts quality radical rapidly reaching recorded reduced reflected regard repetition resonant routine sample sampling scheme science selective setup shape shimming significantly simultaneous simultaneously site slice slices solution spectra spectroscopy spectrum steps strict studies substrates surface swiss system temporal throughput toxicology tumor typically version weeks width