Meeting Banner
Abstract #4056

A Reinvestigation of the Feasibility and Reproducibility of Perfusion MRI in the Kidneys

Wen-Chau Wu1, 2, Mao-Yuan Su3, Chin-Cheng Chang3, Kao-Lang Liu3

1Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan; 2Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 3Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

Arterial spin labeling (ASL) and dynamic contrast enhanced (DCE) imaging are two established MRI techniques for quantitative perfusion measurement although their feasibility in the kidneys is still under investigation. One major challenge is glomerular filtration of the tracers used. Extended biophysical models have been proposed to account for dual outputs and/or inputs of tracers, which usually require additional scans and higher contrast-to-noise ratio (CNR). In this study, we assessed the feasibility and reproducibility of ASL and DCE in renal blood flow measurement using the original models and examined their CNR both in time and in space. Technical limitations were discussed.

Abstract PDF E-Poster Video

Keywords

abdominal acceleration account adults advised affect afterward although amount aorta axial back background barely basis biomedical biophysical blood bolus breath carried carry caused challenge chin clearly coefficient coil comprised concentration confound consent contrast control coronal cortex cortical curves deconvolution delay demand denoted determined diagnostic discarded doses dual duration dynamic elimination enhanced established examination examined expected experiment feasibility feasible filtered filtration fitting flash flexible flow fluctuations flush fold gamma graduate hall healthy holding hours included injected injection input inputs institute instructed inversion investigation kidneys labeling limitations long longer loss marginal materials matrix measured media medical medulla modeling models national noise optimal option original outputs panel particularly pass perfusion physiology post power proposed quantification quantify readout reception recovery related repeated reproducibility reproducible require respectively saturation shot slice slices spin started still studies subject suggesting suppression system takes technical torso tracers transit transmission travel trio turbo usually variate variation water whereas wise written yields