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Abstract #4029

Feeding with Large Amounts of Fructose or Glucose Increases Hepatic Lipid Content Only When Positive Energy Balance Is Achieved

MAGNA25Mary Charlotte Stephenson1, Richard D. Johnston2, Eleanor F. Cox1, Elisa Placidi1, Guruprasad P. Aithal2, Ian A. MacDonald3, Peter G. Morris1

1SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 3School of Biomedical Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Fructose has been linked to rises in obesity and liver disease. This study observes the effects of an isoenergetic diet containing excess fructose or glucose on hepatic and muscle lipid stores, and 31P metabolite levels, and compares these with a hyperenergetic diet with equivalent excess fructose or glucose. We show that 2 weeks of a high fructose isoenergetic diet does not increase lipid deposition. Increasing energy intake leads to increased levels of hepatic lipid and inorganic phosphate. However, these changes occur following hyperenergetic fructose and glucose diets, indicating that the effects are more likely the result of energy overfeeding.

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