Meeting Banner
Abstract #3985

Assessment of Pulmonary Inflammation in a Rat Bleomycin Model Using Oxygen-Weighted Hyperpolarized 3He MRI

Puttisarn Mongkolwisetwara1, Milton Rossman2, Evguenia Arguiri2, Harrilla Profka1, Kiarash Emami1, Yi Xin1, Stephen J. Kadlecek1, Melpo Christofidou-Solomidou2, Rahim

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Medicine, University of Pennsylvania, Philadelphia, PA, United States

Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease. It causes scarring of the lungs and limits oxygen transport across membranes into bloodstream. The disease course of IPF is variable. In this work, hyperpolarized (HP) 3He MRI is used to acquire regional information of oxygen tension, oxygen uptake and fractional ventilation in a rat model of interstitial fibrosis secondary to bleomycin. Significant correlation between oxygen uptake and biological markers of inflammation and fibrosis in lung suggests that the oxygen-weighted HP MRI can be used as a tool for early detection of fibrosis development and evaluate disease progress in humans.

Keywords

absence absolute accord alveolar alveoli animal animals around assays assessed assessment biological blood bloodstream body breath breaths briefly buildup cell cells certainly coil completely compliant confined content control correlation counts cycles damage days depletion described development differentials ding disease drug eight encouraging establishing excessive fact fast fibrosis fixed flow fluid formation fractional free function gradient healthy heterogeneous highlights histology hods hold human hydroxy idea idiopathic induction inflammation inflammatory instillation intro intubated investigate iterative larger lavage leukocyte lung lungs mans maps markers measure mechanically medicine membranes mode model monitor nature observe ongoing overall oxygen passable period placed plot possibly post potentially predefined predicting presentation progression protein pulmonary quired radiology rats real redistribution reduction relationships remain repeated representative respectively respiratory returned scanner scarring sedated sensitive sensitivity series serious several short significantly solved spaces stage still summarizes surgical tend tension term thicker tissue tracheal tuned umber uptake utility ventilated ventilation ventilator white whose yield