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Abstract #3982

Optimal Conditions for Accelerated Imaging of Fractional Ventilation with Hyperpolarized Gas MRI

Kiarash Emami1, Yinan Xu1, Hooman Hamedani1, Harrilla Profka1, Yi Xin1, Puttisarn Mongkolwisetwara1, Stephen J. Kadlecek1, Masaru Ishii2, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

Accelerated imaging of fractional ventilation by parallel imaging effectively reduces the total imaging time and the overall RF-induced signal decay. This in turn improves the accuracy of fractional ventilation measurements, while allowing for a more similar respiratory pattern during HP gas MRI to that of normal breathing. Given the multitude of parameters that define an accelerated imaging protocol (e.g. flip angle and acceleration factor), an objective analysis of these effects can assist in selecting an optimal set of parameters to minimize estimation error while maintaining study requirements.

Keywords

accelerated acceleration according accuracy achievable acquisition acquisitions agree array artifacts assessment attenuation basis behavior beyond blank boxes breath breathe breathing breaths brevity buildup certain coefficient coil coils combined comparable complex computed condition conditions correlation course cycle dashed decay density depolarization described developed diminishing directly diseases dynamic earlier effective error estimation evaluated experiment experimental faster fitting fractional function gain general gets global highly hold humans identical important inaccuracy included indefinitely indicate induces initially inspired interval intervention introduced invasive investigate johns larger least limit linear local long longer loss lung mapping maps marker middle model neck negligible noise nominal noninvasive normalized obstructive optimal overall oxygen pair parallel pertains priori profile pronounced pulmonary pulses reaches receive reconstructed reconstruction recursive reducing reflects regional regression reported represent representative residual resolution respect respectively respiratory response rest scale sensitivity simulated sinusoidal slice slices slower space species spin still surgery synthetic thereby typical useful variation various ventilation volume yield